Therapeutics

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Therapeutics 13 May 2020

Hyperbaric oxygen treatment for COVID-19

An article published in Medical Gas Research discusses the application of Hyperbaric Oxygen Treatment for COVID-19 induced pneumonia/hypoxemia by exploiting Hendry's law

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Scientific Papers 8 May 2020

Innate Immunity against COVID-19

An article published in the Physiological Genomics [https://journals.physiology.org/doi/full/10.1152/physiolgenomics.00033.2020] (American physiological society) suggests immunomodulation through activation

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Scientific Papers 5 May 2020

A human monoclonal antibody blocks SARS-CoV-2 in cell culture

An article published in Nature Communications [https://www.nature.com/articles/s41467-020-16256-y] reports a recombinantly expressed human chimeric 47D11 H2L2 antibody, reformatted to a fully

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Scientific Papers 3 May 2020

Potential use of hydroxychloroquine, ivermectin and azithromycin drugs in fighting COVID-19: trends, scope and relevance

Mini-Review published [https://www.sciencedirect.com/science/article/pii/S2052297520300366#bib14] in New Microbes and New Infections [https://www.sciencedirect.com/science/journal/20522975] journal

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Therapeutics 1 May 2020

Convalescent serum lines up as first-choice treatment for coronavirus

Published in Nature Biotechnology: [https://www.nature.com/articles/d41587-020-00011-1] Antibodies from blood donated by people who recovered from the illness and hyper-immunoglobulins are becoming

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pre-print 24 April 2020

Pharmacology of Chloroquine + Azirthromycin in Mx of COVID-19

A pre-print paper [https://www.mediterranee-infection.com/wp-content/uploads/2020/04/azithroquine_manuscript-soumis.pdf] summarised the pharmacology of Hydroxychloroquine and azithromycin as early treatment options

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Therapeutics 12 April 2020

Yale Medicine (YNHH) COVID-19 Treatment Guidelines

The Yale New Haven Health System [https://www.ynhhs.org/] (YNHH) has released its 'Initial Treatment Algorithm for Hospitalized ADULTS with Non–Severe* COVID-19

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pre-print 12 April 2020

Chloroquine with Azithromycin may have synergistic effects on QT length, needs caution

A pre-print paper (medrxiv) suggests that while, 'short-term hydroxychloroquine treatment is safe, addition of azithromycin may induce heart failure and cardiovascular mortality, potentially due

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Therapeutics 11 April 2020

Convalescent plasma for COVID-19 treatment - Why and How

A peer reviewed article [https://onlinelibrary.wiley.com/doi/abs/10.1111/vox.12926] discusses the use of convalescent plasma, i.e. passive polyclonal antibody

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Therapeutics 11 April 2020

COVID-19 Critical Care Protocol

Eastern Virginia Medical School has released a COVID-19 Critical Care Management Protocol suggesting approaches to prophylaxis and treatment of  COVID-19 based on emerging evidences that

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Scientific Papers 7 April 2020

EIDD-2801, a NHC prodrug inhibits SARS-CoV-2 in cell cultures and mice

A paper published in Science Translational Medicine, reports that, 'prophylactic and therapeutic administration of EIDD-2801, an orally bioavailable NHC-prodrug (β-D-N4-hydroxycytidine-5′-isopropyl ester) - a

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Therapeutics 6 April 2020

Therapeutic plasma exchange for fulminant COVID-19 - Advocacy article

Chinese authorities have reported success treating infected patients with donated plasma from survivors of the illness, the proposed benefit being protective antibodies formed by the

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Clinical Trials 6 April 2020

rsACE2 may Inhibit COVID-19. Clinical Trial to commence

An international team that previously offered the first genetic evidence that Angiotensin converting enzyme 2 (ACE2) is the critical receptor for SARS-CoV and that ACE2

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Therapeutics 6 April 2020

Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

Abstract Background A relatively high mortality of severe coronavirus disease 2019 (COVID‐19) is worrying, the application of heparin in COVID‐19 has been recommended

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Scientific Papers 4 April 2020

Ivermectin is a potent inhibitor of SARS-CoV-2

Ivermectin is an inhibitor of SARS-CoV-2