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The SARS-CoV-2 Spike Protein - drug target

Published 14 April 2020 1 min read

By Jagan Mohan R, MD

The SARS-CoV-2 Spike Protein - drug target

An article title, 'Scientists Scan for Weaknesses in the SARS-CoV-2 Spike Protein' published in The Scientist discusses and reviews the ongoing rush to find targets for antiviral drugs and vaccines, particularly on the Spike Protein that the virus uses to enter cells.

An animation revealing the opening of the SARS-CoV-2 spike protein, which helps it to bind to the ACE2 receptor in human cells FOLDING@HOME AND MAXWELL ZIMMERMAN

An animation showing the SARS-CoV-2 spike protein (gray) with glycans scattered around on its surface. The structure jiggles, which might affect how antibodies or other molecules bind with it. LORENZO CASALINO, ZIED GAIEB, AND ROMMIE AMARO, UC SAN DIEGO

Our first complete model of the SARS-CoV-2 Spike protein in complex with the human ACE2 receptor, with full complex glycosylation added. @PertholdJW made this model, using methods developed by @AysegulTurupcu pic.twitter.com/R1tqi9t9Qc
— Chris Oostenbrink (@mms_boku) March 27, 2020